Recommended pediatric dosing for Humatrope administration
1 Larger doses of somatropin (eg, 0.067 mg/kg/day) are recommended especially in children with height SDS < -3, and/or older pubertal children, and a reduction in dosage (eg, gradually toward 0.033 mg/kg/day) should be considered if substantial catch-up growth is observed during the first few years of therapy.
For SGA children less than 4 years old and with less baseline height DSD values between -2 and -3, consider initiating treatment at a lower dose (eg, 0.033 mg/kg/day), and titrating the dose as needed over time.
1. Dosage should be individualized within recommended range based on growth response; failure to increase height velocity should prompt close assessment.
Recommended adult dosing for Humatrope administration
2. Dose should be adjusted based on clinical response, side effects, and determination of age- and gender-adjusted serum IGF-1 concentration.
3. May be used without consideration of body weight, and can be increased gradually every 1 to 2 months by increments of approximately 0.1 to 0.2 mg/day.
4. The dose may be increased to a maximum of 0.0125 mg/kg (12.5 μg/kg) daily.