How Do I Use the HumatroPen®?

You will receive a Pen User Manual with the HumatroPen®, and instructions on mixing the Humatrope with your cartridges (also known as reconstitution). Carefully read the User Manual before using the HumatroPen®, and read the Patient Information with mixing instructions before using a new cartridge. You can also view the User Manual for the HumatroPen® by selecting one of the links in the User Manual section of this page.

SELECT SAFETY INFORMATION

Do not take Humatrope if you are having serious complications after having open heart surgery, abdominal surgery, or serious injuries involving many body systems, or are having life-threatening breathing problems. Deaths have been reported in such cases.

Pen User Manuals

Each patient or the patient's parent or guardian must carefully read the HumatroPen® User Manual before using the HumatroPen® (please see links below). In addition, if you have been prescribed the Humatrope vial and syringe, you will receive the Humatrope Vial (5 mg) Instructions for Use.

HumatroPen Images

Humatrope® is available in 6 mg, 12 mg, and 24 mg cartridges for use in the HumatroPen® injection device.

Do You Need Injection Training?

Your doctor’s office may provide injection training or prefer that you contact Humatrope DirectConnect. We have experienced Nurse Educators who will come to your home* or location of your choice to help you learn how to use the HumatroPen®. They can spend as much time as you need to help you or your child get ready to start taking Humatrope. After you receive your Humatrope shipment, please call 1-84Humatrope (1-844-862-8767) Monday through Friday, 8 AM to 8 PM Eastern time, to schedule injection training with a Nurse Educator.

Go to Pen Training

*In-home training subject to state regulations and availability of trained Nurse Educators.

Images of 5-mg vial of Humatrope and 5-mL vial of diluent.

Humatrope is also available in a vial for use with a syringe and needle

  • Vial kit contains a 5-mg vial of Humatrope and a 5-mL vial of diluent (the liquid used to mix the dried Humatrope).
  • Humatrope must be kept refrigerated (36° to 46° F [2° to 8° C]) before and after it is mixed. Do not freeze. Once Humatrope has been mixed and is in liquid form, cartridges must be used within 28 days and vials must be used within 14 days. Throw away any unused Humatrope in a cartridge after 28 days and in a vial after 14 days. Before giving an injection, check the manufacturer's expiration date on the cartridge or vial. Do not use the cartridge or vial if it has expired.
  • Before using the Humatrope vial and syringe, print and carefully read the Humatrope Vial Instructions for Use.

Helping You Find Answers

If you need technical support about using Humatrope, your HumatroPen®, or injection supplies, call your healthcare professional or call The Lilly Answers Center at 1-800-545-5979 from 9 AM to 8 PM Eastern time. To schedule injection training, or for follow-up questions, call Humatrope DirectConnect at 1-84Humatrope (1-844-862-8767), Monday through Friday from 8 AM to 8 PM Eastern time.

FAQs

Below are some answers to questions you may have about the HumatroPen® 6 mg, 12 mg, and 24 mg injection devices.
See Full Pen User Manual that accompanies the HumatroPen® 6mg, 12mg, and 24mg.

View options

What happens if I forget to take a dose?

Plus
  • If you miss a dose of Humatrope, you should simply take the next dose at the regularly scheduled time. Do not double up on doses.

What kinds of needles can be used with the HumatroPen® injection devices?

Plus
  • Pen needles are not included with the HumatroPen® injection device. You may need a prescription to obtain the needles from your pharmacist.
  • BD Pen needles are suitable for use with the HumatroPen®.
  • Ask your healthcare professional what needle gauge and length is best to use.
  • Follow your healthcare professional's instructions on safe handling of needles.
    BD and BD Logo are trademarks of Becton, Dickinson and Company.

Must a new needle be used for each injection?

Plus
  • Yes, a new needle must be used for each injection.
  • Remove the needle immediately after each injection and discard into a puncture-proof container. Use a new needle for each injection. This will help minimize the risk of infection, prevent leakage of Humatrope, keep out air bubbles, and reduce needle clogs.

How do I throw away used needles?

Plus
  • Throw away used needles in a puncture-proof container. Follow your healthcare professional's instructions on how to do this safely. Keep sharps container out of reach of children and pets.

Do I need to perform the New Cartridge Setup before every dose?

Plus
  • No. The New Cartridge Setup should be performed only once for each Cartridge, just before a new Cartridge is used for the first time.
  • The purpose of the setup is to make sure the HumatroPen® and Cartridge are ready to use.
  • If you repeat the New Cartridge Setup before each routine dose, you may run out of Humatrope early. The small amount of product used in the New Cartridge Setup will not affect the supply of Humatrope. Confirm that you have a 6 mg, 12 mg, or 24 mg Humatrope cartridge to match the corresponding HumatroPen®. This is important to ensure the prescribed dose of Humatrope is given. If it does not match, DO NOT USE and call The Lilly Answers Center at 1-800-545-5979 from 9 AM to 8 PM Eastern time, or call your healthcare professional.

What should I do if the Cartridge Label and HumatroPen® do not match?

Plus
  • DO NOT USE the HumatroPen® if the mg number (6 mg, 12 mg, or 24 mg) on the Humatrope Cartridge label does not match the number on the end of the Dose Knob and Front Housing of the HumatroPen®. This is important to ensure the correct dose of Humatrope is given.
  • Contact your healthcare professional for assistance or to obtain a replacement HumatroPen®.

What should I do if the Humatrope is not clear after mixing?

Plus
  • Be sure to gently invert the Cartridge up and down 10 times. DO NOT SHAKE. Then, let the Cartridge sit for at least 3 minutes. If the solution remains cloudy or has particles, gently invert the Cartridge up and down 10 more times. Let the Cartridge sit for 5 more minutes.
  • If the solution remains cloudy or contains particles after reconstitution (mixing), DO NOT USE. Contact your healthcare professional for assistance.

Why are there air bubbles in the Cartridge?

Plus
  • Air bubbles may remain in the Cartridge after reconstitution (mixing).
  • If the HumatroPen® is stored with a needle attached, air bubbles may form in the Cartridge. DO NOT STORE the HumatroPen® with a needle attached.
  • If air bubbles are present, perform the New Cartridge Setup to remove air bubbles from the Cartridge.
  • A small air bubble is normal. It will not cause any harm nor affect the dose.

Why doesn't the Screw move out when there is no Cartridge attached to the HumatroPen®?

Plus
  • The Screw may not move out when you push the Injection Button unless there is a Cartridge in the HumatroPen®. This feature allows you to easily push the Screw into the HumatroPen® Body when replacing a Cartridge.
  • Once a Cartridge is attached, the Screw will move out when the Injection Button is pushed.

What should I do if I can't attach the Cartridge to the HumatroPen® Body?

Plus
  • Check that the Cartridge is not damaged or broken.
  • Carefully line up the Cartridge with the HumatroPen® Body and screw together until secure. If the Cartridge and HumatroPen® cannot be screwed together, contact your healthcare professional.

Why is it difficult to push the Injection Button when I try to inject the dose?

Plus
  • The needle may be clogged. Try attaching a new needle.
  • Pushing the Injection Button down quickly may make the Injection Button harder to push. Pushing the Injection Button more slowly may make it easier.
  • Using a larger-diameter needle will make it easier to push the Injection Button during injection. Ask your healthcare professional which needle is best for you or your child.
  • The Injection Button may become harder to push if the inside of the HumatroPen® gets dirty.

Why doesn't the Dose Knob go to zero when I inject the dose?

Plus
  • This can happen if the Humatrope Cartridge does not have enough Humatrope left in it for the full dose. It is possible to set a dose larger than the amount of Humatrope left in the Cartridge. At the end of the injection, the number in the Dose Window should be 0.00. If it is not, the number showing in the window is the amount of Humatrope that WAS NOT delivered. Consult with your healthcare professional on how to handle a partial dose. Remove the needle and the empty cartridge. For the next daily use, attach a new Cartridge as shown in the HumatroPen® User Manual, and continue with New Cartridge Setup.

Why do I see Humatrope leaking from the needle after I have finished the injection?

Plus
  • It is normal for a single drop to remain on the tip of the needle after the injection is complete. If you see more than one drop:
    • The full dose may not have been delivered. DO NOT INJECT another dose. Consult with your healthcare professional for assistance.
    • To prevent this, for the next dose, firmly push and hold the Injection Button in and slowly count to five.

How can I tell when the injection is complete?

Plus
  • The injection is complete when:
    • You have slowly counted to five while you are still holding the Injection Button in and before you remove the needle from the skin,
    • AND
    • 0.00 is in the center of the Dose Window.

What if I leave my HumatroPen® at room temperature?

Plus
  • Call 1-800-LillyRx (1-800-545-5979) from 9 AM to 8 PM Eastern time to receive additional guidance/information.

Indications and Important Safety Information for Humatrope

Humatrope® (somatropin for injection) is used to treat:

  • Children who do not make enough growth hormone on their own, have short stature associated with Turner syndrome, or have SHOX deficiency; have idiopathic short stature, which means they are shorter than 98.8% of other children of the same age and sex, are growing at a rate not likely to allow them to reach normal adult height, and for whom no other cause of short stature can be found; were born smaller than normal for the number of weeks of pregnancy and who do not catch up in height by 2 to 4 years of age.
  • Adults who have growth hormone deficiency that began either in adulthood (as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma) or in childhood. Patients treated for growth hormone deficiency in childhood whose bones have stopped growing should be reevaluated to determine if they should continue growth hormone.

Important Safety Information for Humatrope

What is the most important information I should know about Humatrope?

  • Do not take Humatrope if you are having serious complications after having open heart surgery, abdominal surgery, or serious injuries involving many body systems, or are having life-threatening breathing problems. Deaths have been reported in such cases.
  • Do not use Humatrope in children with Prader-Willi syndrome who are severely obese or have a history of blocked upper airways or other severe breathing problems, or sleep apnea. Deaths have been reported in such cases. Humatrope is not approved for the treatment of patients with Prader-Willi syndrome.
  • Do not use Humatrope if you have active cancer. Growth hormone deficiency can be an early sign of some tumors in the brain or pituitary gland. The presence of these types of tumors should be ruled out by your doctor before you start Humatrope.
  • Serious allergic reactions have been reported with Humatrope. Humatrope is contraindicated if you know you have allergies to growth hormone or any of its ingredients. Tell your doctor if you have an allergic reaction. Do not mix Humatrope with the supplied diluent if you are allergic to metacresol or glycerin.
  • Your doctor should check your blood sugar regularly while you are taking Humatrope, especially if you have diabetes, pre-diabetes, or risk factors for diabetes. New cases of type 2 diabetes have been reported in patients taking Humatrope.
  • Tell your doctor if you have any visual changes accompanied by headache, nausea, and/or vomiting while taking Humatrope. This may be a sign of increased pressure in the brain.
  • Adults may retain water during Humatrope treatment. This may be brief and may increase with higher doses of Humatrope.
  • If you have hypoadrenalism and are on glucocorticoid replacement therapy, your doctor may increase your dosage when you initiate growth hormone treatment.
  • Your doctor should test your thyroid function periodically during Humatrope therapy. Thyroid hormone treatment may need to be started or adjusted.
  • Fracture in the ball of the hip joint can occur in children who have endocrine problems and in children who have rapid growth. Any child taking Humatrope who develops a limp or complains of hip or knee pain should be seen by a doctor to check for this.
  • Progression of curvature of the spine (scoliosis) can occur in children who have rapid growth. Humatrope has not been shown to increase the occurrence of this condition. If the child has scoliosis, the doctor should carefully monitor the progression of the scoliosis during Humatrope treatment.
  • Cases of pancreatitis (inflammation of the pancreas) have been reported rarely in children and adults receiving growth hormone. Consult a doctor if you develop abdominal pain while taking Humatrope.
  • You should rotate your injection sites to avoid breakdown of skin and fat. Seek prompt medical attention for any allergic reaction you experience to the injection of Humatrope.

Who should not take Humatrope?

Humatrope should not be used by:

  • People with serious complications after having open heart surgery, abdominal surgery, serious injuries involving many body systems, or with life-threatening breathing problems
  • Children with Prader-Willi syndrome who are severely obese or have a history of severe breathing problems
  • People with active cancer
  • People who have had an allergic reaction to growth hormone
  • People with diabetic disease of the retina (the lining in the back of the eyeball)
  • Children who have closed growth plates in their bones

What should I tell my doctor before taking Humatrope?

Tell your doctor about all of your prescription and over the counter drugs, including cyclosporine, hormone replacement therapy, insulin or other diabetes medications, drugs containing steroids, or drugs for seizures. These medications may need to be adjusted while taking Humatrope.

What are the possible side effects of Humatrope?

Common side effects reported in adults and children taking Humatrope include injection site reactions, allergic reactions to the diluent, and hypothyroidism. Additional common side effects in adults include swelling, joint pain, muscle pain, carpal tunnel syndrome, unusual skin sensations, and high blood sugar. You are encouraged to report negative side effects of prescription drugs to the Food and Drug Administration (FDA). Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store Humatrope?

Humatrope must be kept refrigerated (36° to 46°F [2° to 8°C]) before and after it is mixed. Do not freeze. Once Humatrope has been mixed and is in liquid form, cartridges must be used within 28 days and vials must be used within 14 days. Throw away any unused Humatrope in a cartridge after 28 days and in a vial after 14 days. Before giving an injection, check the manufacturer’s expiration date on the cartridge or vial. Do not use the cartridge or vial if it has expired.

Humatrope is available by prescription only.

Click to access Patient Information-Cartridge, Patient Information-Vial, and Full Prescribing Information.

See Full Pen User Manual that accompanies the HumatroPen® 6 mg, 12 mg, and 24 mg.

HG CON ISI 14OCT2016