How do I use the HumatroPen?
You will receive a Pen User Manual with the HumatroPen®, and instructions on mixing the Humatrope with your cartridges (also known as reconstitution). Carefully read the User Manual before using the HumatroPen®, and read the Patient Information with mixing instructions before using a new cartridge. You can also view the User Manual for the HumatroPen® by selecting one of the links in the User Manual section of this page.
Select Safety Information
Do not take Humatrope if you are having serious complications after having open heart surgery, abdominal surgery, or serious injuries involving many body systems, or are having life-threatening breathing problems. Deaths have been reported in such cases.
Pen User Manuals
Each patient or the patient's parent or guardian must carefully read the HumatroPen® User Manual before using the HumatroPen® (please see links below). In addition, if you have been prescribed the Humatrope vial and syringe, you will receive the Humatrope Vial (5 mg) Instructions for Use.
Would you like to have in-person injection training from a Nurse Educator?
Your doctor’s office may provide injection training or prefer that you contact Humatrope DirectConnect. We have experienced Nurse Educators who will come to your home* or location of your choice to help you learn how to use the HumatroPen®. They can spend as much time as you need to help you or your child get ready to start taking Humatrope. After you receive your Humatrope shipment, please call 1-84Humatrope (1-844-862-8767) Monday through Friday, 8 AM to 8 PM Eastern Time, to schedule injection training with a Nurse Educator.
*In-home training subject to state regulations and availability of trained Nurse Educators.
Humatrope is also available in a vial for use with a syringe and needle
- Vial kit contains a 5-mg vial of Humatrope and a 5-mL vial of diluent (the liquid used to mix the dried Humatrope).
- Humatrope must be kept refrigerated (36° to 46° F [2° to 8° C]) before and after it is mixed. Do not freeze. Once Humatrope has been mixed and is in liquid form, cartridges must be used within 28 days and vials must be used within 14 days. Throw away any unused Humatrope in a cartridge after 28 days and in a vial after 14 days. Before giving an injection, check the manufacturer's expiration date on the cartridge or vial. Do not use the cartridge or vial if it has expired.
- Before using the Humatrope vial and syringe, print and carefully read the Humatrope Vial Instructions for Use
When taking Humatrope (somatropin for injection) remember
Below are some answers to questions you may have about the HumatroPen® 6 mg, 12 mg, and 24 mg injection devices.
See Full Pen User Manual that accompanies the HumatroPen® 6mg, 12mg, and 24mg.
- If you miss a dose of Humatrope, you should simply take the next dose at the regularly scheduled time. Do not double up on doses.
- Pen Needles are not included with the HumatroPen® injection device. You may need a prescription to obtain the Needles from your pharmacist.
- BD Pen Needles are suitable for use with the HumatroPen®.
- Ask your healthcare professional what Needle gauge and length is best to use.
- Follow your healthcare professional's instructions on safe handling of Needles.
BD and BD Logo are trademarks of Becton, Dickinson and Company.
- Yes, a new needle must be used for each injection.
- Remove the needle immediately after each injection and discard into a puncture-proof container. Use a new needle for each injection. This will help minimize the risk of infection, prevent leakage of Humatrope, keep out air bubbles, and reduce needle clogs.
- Throw away used needles in a puncture-proof container. Follow your healthcare professional's instructions on how to do this safely. Keep sharps container out of reach of children and pets.
- No. The New Cartridge Setup should be performed only once for each Cartridge, just before a new Cartridge is used for the first time.
- The purpose of the setup is to make sure the HumatroPen® and Cartridge are ready to use.
- If you repeat the New Cartridge Setup before each routine dose, you may run out of Humatrope early. The small amount of product used in the New Cartridge Setup will not affect the supply of Humatrope. Confirm that you have a 6 mg, 12 mg, or 24 mg Humatrope cartridge to match the corresponding HumatroPen®. This is important to ensure the prescribed dose of Humatrope is given. If it does not match, DO NOT USE and call The Lilly Answers Center at 1-800-LillyRX (1-800-545-5979) from 9 AM to 8 PM Eastern time, or call your healthcare professional.
- DO NOT USE the HumatroPen® if the mg number (6 mg, 12 mg, or 24 mg) on the Humatrope Cartridge label does not match the number on the end of the Dose Knob and Front Housing of the HumatroPen®. This is important to ensure the correct dose of Humatrope is given.
- Contact The Lilly Answers Center (1-800-545-5979) or your healthcare professional for assistance or to obtain a replacement HumatroPen.
- Be sure to gently invert the Cartridge up and down 10 times. DO NOT SHAKE. Then, let the Cartridge sit for at least 3 minutes. If the solution remains cloudy or has particles, gently invert the Cartridge up and down 10 more times. Let the Cartridge sit for 5 more minutes.
- If the solution remains cloudy or contains particles after reconstitution (mixing), DO NOT USE. Contact your healthcare professional for assistance.
- Air bubbles may remain in the Cartridge after reconstitution (mixing).
- If the HumatroPen® is stored with a needle attached, air bubbles may form in the Cartridge. DO NOT STORE the HumatroPen® with a needle attached.
- If air bubbles are present, perform the New Cartridge Setup to remove air bubbles from the Cartridge.
- A small air bubble is normal. It will not cause any harm nor affect the dose.
- The Screw may not move out when you push the Injection Button unless there is a Cartridge in the HumatroPen®. This feature allows you to easily push the Screw into the HumatroPen® Body when replacing a Cartridge.
- Once a Cartridge is attached, the Screw will move out when the Injection Button is pushed.
- Check that the Cartridge is not damaged or broken.
- Carefully line up the Cartridge with the HumatroPen® Body and screw together until secure. If the Cartridge and HumatroPen® cannot be screwed together, contact your healthcare professional.
- The Needle may be clogged. Try attaching a new Needle.
- Pushing the Injection Button down quickly may make the Injection Button harder to push. Pushing the Injection Button more slowly may make it easier.
- Using a larger-diameter Needle will make it easier to push the Injection Button during injection. Ask your healthcare professional which Needle is best for you or your child.
- The Injection Button may become harder to push if the inside of the HumatroPen® gets dirty.
- This can happen if the Humatrope Cartridge does not have enough Humatrope left in it for the full dose. It is possible to set a dose larger than the amount of Humatrope left in the Cartridge. At the end of the injection, the number in the Dose Window should be 0.00. If it is not, the number showing in the window is the amount of Humatrope that WAS NOT delivered. Consult with your healthcare professional on how to handle a partial dose. Remove the needle and the empty cartridge. For the next daily use, attach a new Cartridge as shown in the HumatroPen® User Manual, and continue with New Cartridge Setup.
- It is normal for a single drop to remain on the tip of the needle after the injection is complete. If you see more than one drop:
- The full dose may not have been delivered. DO NOT INJECT another dose. Consult with your healthcare professional for assistance.
- To prevent this, for the next dose, firmly push and hold the Injection Button in and slowly count to five.
- The injection is complete when:
- You have slowly counted to five while you are still holding the Injection Button in and before you remove the needle from the skin,
- 0.00 is in the center of the Dose Window.
Still have questions?
Helping You Find Answers
If you need technical support about using Humatrope, your HumatroPen®, or injection supplies, call your healthcare professional or call The Lilly Answers Center at 1-800-545-5979 from 9 AM to 8 PM Eastern time.